Popper is a slang term given broadly to drugs of the chemical class called alkyl nitrites that are inhaled. Most widely sold products include the original isoamyl nitrite or isopentyl nitrite , and isopropyl nitrite. Isobutyl nitrite was also used until it was banned by the European Union. In some countries, to evade anti-drug laws, poppers are labelled or packaged as room deodorizers, leather polish, or tape head cleaner. Popper use has a relaxation effect on involuntary smooth muscles , such as those in the throat and anus. The drug is also used or for recreational drug purposes, typically for the "high" or "rush" that the drug can create. Poppers were part of club culture from the mids disco scene and returned to popularity in the s and s rave scene.
Anal fissures: tear-inducing tears
Recent studies indicate that nitroglycerin NTG can produce beneficial clinical effects in healing anal fissures through the relaxation of the internal anal sphincter. The in vivo relaxation effects of NTG on the anorectal smooth muscle have not been studied and it is not known whether this tissue may also exhibit pharmacological tolerance toward NTG. We have developed an in vivo procedure in the anaesthetized rat that permits continual monitoring of anorectal pressure after intravenous i. Sustained relaxation effects on anorectal pressure were also observed after continuous intra-rectal infusions of NTG. Two-hours of i. NTG infusion led to a significant reduction in the mean arterial blood pressure MAP response toward a i. In contrast, relaxation of the anorectal pressure toward the challenge dose was not altered after NTG infusion. In isolated tissues, cyclic GMP accumulation was significantly decreased after NTG pre-incubation in the rat aorta but not in the rat anorectal smooth muscle and anal sphincter. These results indicate that the relaxation response toward NTG was not diminished in the anorectum under conditions that produced vascular tolerance. Thus, NTG causes significant and sustained in vivo relaxation of anorectal smooth muscle in the anaesthetized rat without evidence of tolerance development.
From relieving chest pain to cleaning pots and pans, the historic gay club drug has more uses than just relaxing your sphincter. Instead, as was theorized on a recent Autopsy, Last Hours of… episode about her death, she was using the ever-popular club drug to treat her heart and chest pain. A medicinal pop, if you will. That got me thinking: If poppers are just a simple vasodilator and a muscle relaxant — and nearly every organ and muscle in your body could benefit from a little extra blood flow and relaxation — what else could they be used for? As it turns out, the answer is a reluctant, skeptical yes. Because they dilated blood vessels, they allowed the heart to get more oxygen, thereby relieving the pain and shortness of breath associated with the condition much like nitroglycerin. However, while they were used specifically for this purpose for over a hundred years after their invention in , they fell out of favor b ecause of all the side effects they had. Elizabeth Hartney warns that you should never use them for the treatment of angina, or any other cardiovascular condition, without the supervision of a doctor.
Anal fissure is a common problem and is associated with severe pain and rectal bleeding. It is a longitudinal or elliptical ischemic ulcer in the anoderm, extending below the dentate line to the anal verge. A retrospective pilot study 6 and another prospective trial 7 to analyze the manometric and clinical results on this technique have already been published and this study is being presented with a longer follow-up of 24 months.. Between February and August , patients of chronic anal fissure who were nonresponders to medical therapy [analgesics, stool softeners and nitroglycerine ointment] were treated with this procedure. Eleven patients were lost to follow-up and were excluded. The remaining patients were enrolled in the study men, women; mean age 29 years, range years..